Effects of magnesium sulfate on the clinical course and GCS of patients with a severe diffuse axonal injury

Authors

  • Moslem Shakeri Associate Professor of Neurosurgery,Tabriz University of Medical Sciences, Tabriz, Iran.
  • Firooz Salehpour Professor of Neurosurgery.Tabriz University of Medical Sciences, Tabriz, Iran.
  • Ali Ahmadvand Professor of Neurosurgery.Tabriz University of Medical Sciences, Tabriz, Iran.
  • Rozita Jafari M.D., Imam Reza Teaching Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Abdolrasoul Safaiyan Associate Professor of Vital Statistics, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Ali Meshkini Associate Professor of Neurosurgery,Tabriz University of Medical Sciences, Tabriz, Iran.

Keywords:

Severe diffuse axonal injury, Magnesium sulfate, Outcome

Abstract

Background and Objective: Previous studies have shown that magnesium sulfate (MgSO4) administered in a patient with a diffuse axonal injury (DAI) can serve as a useful neuroprotective agent. The present study was conducted to examine whether magnesium sulfate has a therapeutic efficacy and safety in patients with a severe diffuse axonal injury.

Methods: Adult patients admitted within 1 hour of a closed Traumatic Brain Injury (TBI) with a severe diffuse axonal injury that met eligibility criteria were randomly selected and divided into two groups. Our treatment guidelines consisted of an initial loading dose of 50 mg/kg magnesium sulfate and then 50 mg/kg QID (quarter in die) up to 24 hours after the trauma. The outcome measures were mortality, Glasgow Coma Scale (GCS) score, and motor function scores which were assessed up to 2 months post-trauma.

Results: Magnesium showed a significant positive effect on GCS score at 2 months post-trauma (P=0.03).  Motor functioning scores of patients in the MgSO4 group were higher than those in the control group but this was not statistically significant (P = 0.51).

Conclusion: Findings of the present study demonstrated that administration of magnesium sulfate following severe DAI can have neuroprotective effect.

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Published

2012-12-09

How to Cite

Shakeri, M., Salehpour, F., Ahmadvand, A., Jafari, R., Safaiyan, A., & Meshkini, A. (2012). Effects of magnesium sulfate on the clinical course and GCS of patients with a severe diffuse axonal injury. Journal of Injury and Violence Research, 4(3). Retrieved from https://jivresearch.org/jivr/index.php/jivr/article/view/418

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