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Mahmoudreza Moradi Katayoun Derakhshandeh Babak Karimian Mahtab Fasihi

Abstract

BACKGROUND: Evaluation of the safety and efficacy of intraurethral Mitomycin C (MMC) hydrogel for prevention of post-traumatic anterior urethral stricture recurrence after internal urethrotomy.

METHODS: A thermoresponsive hydrogel base consisting of 0.8 mg MMC with 1cc water and propylene glycol to PF-127 poloxamer was used in theater.  40 male patients with short, non-obliterated, urethral stricture were randomized into 2 groups:  control and MMC. After internal urethrotomy, the MMC group patients received the MMC-Hydrogel while the others were just catheterized. Both groups had their catheters for at least 1 week. After surgery, they were followed up by means of medical history and physical examination, monitoring voiding patterns and retrograde urethrogram at 1 month, 6 months and 1 year after surgery.

RESULTS: 40 male patients between 14 to 89 years old (Mean = 54.15) underwent internal urethrotomy. The average age for the control and MMC group was 54.55±21.25 and 53.75±24.75 respectively. In a comparison of age between the two groups, they were matched. (P=0.574)Stricture length was 10.7±5.9 and 9.55±4.15 mm for the control and MMC group respectively.  There were no statistically meaningful differences between the two groups. (P=0.485) Fifteen patients had a history of one previous internal urethrotomy which in a comparison between the two groups meant there was no meaningful difference. (P = 0.327) During postoperative follow up, total urethral stricture recurrence happened in 12 patients: 10 patients (50%) in control group and 2 patients (10%) in MMC group. The difference was statistically significant (P = 0.001). There were no significant complications associated with the MMC injection in our patients.

CONCLUSIONS: Based on our results, MMC Hydrogel may have an anti-fibrotic action preventing post-traumatic anterior urethral stricture recurrence with no side effects on pre-urethral tissue. Due to our study limitations, our follow up time and the small number of patients, our results were not conclusive and further studies will be needed with a longer follow up time.

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How to Cite
MORADI, Mahmoudreza et al. Safety and efficacy of Intraurethral Mitomycin C Hydrogel for prevention of post-traumatic anterior Urethral stricture recurrence after internal urethrotomy. Journal of Injury and Violence Research, [S.l.], v. 8, n. 2, p. 75-80, apr. 2016. ISSN 2008-4072. Available at: <http://jivresearch.org/jivr/index.php/jivr/article/view/812>. Date accessed: 17 dec. 2017.
Keywords
Mitomycin C(MMC); Urethral stricture; Thermoresponsive Hydrogel; Internal urethrotomy
Section
Original Research Article

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