Moslem Shakeri Firooz Salehpour Ali Ahmadvand Rozita Jafari Abdolrasoul Safaiyan Ali Meshkini


Background and Objective: Previous studies have shown that magnesium sulfate (MgSO4) administered in a patient with a diffuse axonal injury (DAI) can serve as a useful neuroprotective agent. The present study was conducted to examine whether magnesium sulfate has a therapeutic efficacy and safety in patients with a severe diffuse axonal injury.

Methods: Adult patients admitted within 1 hour of a closed Traumatic Brain Injury (TBI) with a severe diffuse axonal injury that met eligibility criteria were randomly selected and divided into two groups. Our treatment guidelines consisted of an initial loading dose of 50 mg/kg magnesium sulfate and then 50 mg/kg QID (quarter in die) up to 24 hours after the trauma. The outcome measures were mortality, Glasgow Coma Scale (GCS) score, and motor function scores which were assessed up to 2 months post-trauma.

Results: Magnesium showed a significant positive effect on GCS score at 2 months post-trauma (P=0.03).  Motor functioning scores of patients in the MgSO4 group were higher than those in the control group but this was not statistically significant (P = 0.51).

Conclusion: Findings of the present study demonstrated that administration of magnesium sulfate following severe DAI can have neuroprotective effect.


How to Cite
SHAKERI, Moslem et al. Effects of magnesium sulfate on the clinical course and GCS of patients with a severe diffuse axonal injury. Journal of Injury and Violence Research, [S.l.], v. 4, n. 3, dec. 2012. ISSN 2008-4072. Available at: <http://jivresearch.org/jivr/index.php/jivr/article/view/418>. Date accessed: 13 dec. 2017.
Severe diffuse axonal injury, Magnesium sulfate, Outcome
Poster Abstracts

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