Sohrab Shahzadi Parisa Azimi Mohammad Ali Bitaraf Maziar Azar Mazdak Alikhani Alireza Zali Sohrab Sadeghi Soraya Salmanian


Background and Objective: The present study aims to evaluate  the Graded Prognostic Assessment (GPA) score for predicting overall survival in patients diagnosed with brain metastases undergoing Gamma-knife radiosurgery.

Methods: This was a cross sectional study conducted on the patients diagnosed with brain metastases undergoing Gamma-knife radiosurgery during 2003 to 2011. Clinical and radiological parameters were evaluated, and the GPA score were determined. Kaplan–Meier and log-rank tests were used to assess prognostic factors of the GPA.

Results: Two hundred and twenty patients were eligible to enter the study during the eight years course of study. The mean age of the patients was 54 ± 12.7 years (ranged 19 to 82 years) and were followed up for an average of 7 (range=1-25) months post Gamma-knife surgery. Median survival times according to the GPA were: GPA 0–1, 4 ± 0.4 months; GPA 1.5–2.5, 6 ± 0.7 months; GPA 3, 9 ± 0.9 months; and GPA 3.5–4.0, 12 ± 1.8 months and overall survival were 7 ± 0.6 months. The level of statistical significance among GPA groups was p < 0.0001.

Conclusion: It seems that the preoperative GPA is able to predict Gamma-knife radiosurgery results in patients with brain metastases. However, the results should be confirmed with further clinical trial assessments.


How to Cite
SHAHZADI, Sohrab et al. A graded prognostic assessment scale to predict overall survival in patients diagnosed with brain metastases undergoing Gamma-knife radiosurgery. Journal of Injury and Violence Research, [S.l.], v. 4, n. 3, nov. 2012. ISSN 2008-4072. Available at: <http://jivresearch.org/jivr/index.php/jivr/article/view/350>. Date accessed: 24 mar. 2018.
Brain metastases, GPA Score, Gamma-knife radiosurgery, predict
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